(That said, some paint manufacturers refer to the preservatives as “thiazoles” or “thiazoline compounds”.). In North America (and perhaps elsewhere outside the EU), MI and/or MCI can theoretically ‘hide’ in the term ‘fragrance’ or ‘parfum’, given it is one of the permitted chemicals in any blend that can be described as such. A few weeks ago my eye was caught by the name of a study in the journal Contact Dermatitis, entitled “Preventing relapses of airborne allergic contact dermatitis to isothiazolinones in wall paint by painting over with an isothiazolinone‐free paint”. "[12] Shortly thereafter, Canada moved to adopt similar measures in its Cosmetic Ingredients Hotlist. There is always the possibility that if you react to one or more of the isothiazolinones and therefore have a tendency to allergies or contact dermatitis, you may react to other ingredients, such as other preservatives, or fragrances in cosmetics and household goods. Again, these may be seen on an MSDS, and pose a danger because when contacting manufacturers for their MI status, unwitting customer service agents may not be aware that these represent isothiazolinone preservatives. Potassium sorbate / sorbic acid [4] Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species. The full list of permitted compounds in fragrance, Isothiazolinone test kits, dish soaps and cosmetics, Coronavirus and allergic contact dermatitis, MI free hairspray, hair mousse and hair gel, Suma’s Ecoleaf Hand Soap: reporting non-compliant use of benzisothiazolinone. [15][16] Due to increased use of isothiazolinone-based preservatives in recent years, an increase in reported incidences of contact allergy to this product has been reported. 55965-84-9 – MI / MCI Blend. Allergy to MI can be missed by only testing to isothiazolinone mix. Alternative names of isothiazolinone mix Kathon®, Kathon CG®, Kathon 886® Methylchloroisothiazolinone (MCI) Methylisothiazolinone (MI), a related allergen, was declared the Contact Allergen of the Year for 2013 by the For additional information about products that might contain Methylisothiazolinone , visit the Household Products Database online at the United States National Library of Medicine. Methylisothiazolinone and other isothiazolinone-derived biocides are utilized for controlling microbial growth in water-containing solutions. The risk is probably very low. The committee concluded: “Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer. Lonzaserve(R) PC 26172-55-4 – Methylchloroisothiazolinone (MCI) This substance is a preservative used in personal hygiene products (suchas shampoos, lotions, emulsions, and sun screens), and in industrial coolingoils, cutting oils, and paper finishes. Some links on MI Free are affiliated. names for the heterocyclic organic compounds that conform to the formulae:",2' Methyl isoth iazol inone Methylchloroisothiazolinone Other names for Methylisothiazolinone (CAS No. 1,2-benzisothiazol-3(2H)-one Chloromethylisothiazolinone (CMIT) (alternative for methylchloroisothiazolinone) [14], Methylisothiazolinone is used commonly in products in conjunction with methylchloroisothiazolinone, a mixture sold under the registered trade name Kathon CG. • Methylisothiazolinone (MI) or 2-methyl-4-isothiazolin-3-one; 2-methyl-3(2H)-isothiazolone; 2-methyl-2H-isothiazol-3-one What should you look for and avoid? If you need to scrutinise lists of ingredients, check for the “isothiazol” string of letters, which is the typical ‘giveaway’, among all the numbers, brackets and hyphens. This ingredient has recently been blamed for a rise in the skin disease Eczema and many other allergic reactions. Methylisothiazolinone commonly goes by MIT, but according to the Environmental Protection Agency (EPA), the Cosmetic Ingredient Review, PubChem, and ChemSpider, it can go by some of the following names as well: Kathon CG / LX / WT Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. Remember that fragrances can trigger allergies in their own right. Very small companies sometimes get these things a bit wrong and put the trade name on. They may also appear on other products, such as household cleaning goods and other products. This list is by no means exhaustive. [citation needed] Colgate-Palmolive had added it as an ingredient in a mouthwash put onto the market in August 2014 with the name Colgate Total Lasting White. Sodium benzoate / benzoic acid Methylisothiazolinone, MIT or MI is the latest approved preservative in Europe and it’s very very commonly used in producing skin care products. Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5-15% of CMIT/MIT. To submit resources or links, please fill out the submission form at the top of this page. [6] These compounds are present in a very large number of commonly used cosmetics. Since 2005, it has been widely used in cosmetics and household products, such as moist wipes, shampoos, cleaners and liquid laundry products. Methylisothiazolinone and methylchloroisothiazolinone allergy — news, information and support. For more information about it, see our article here. Phenoxyethanol Comprehensive Toxicology Information HSDB in Although the name sounds similar, it is structurally different and is highly unlikely to cause an allergic reaction in people with an MIT or Kathon allergy. INCI methylisothiazolinone 3.1.2. Readily misc in water, lower alcohols, glycols, other hydrophilic organic solvents. methylisothiazolinoneというのは日本名でいうどういう物質のことなのでしょうか?methylisothiazolinone メチルイソチアゾリノンmethylchloroisothiazolinone メチルクロロイソチアゾリノン化学の論文などでは、No.1 の通り番号 Common names and synonyms CAS number EC number methylisothiazolinone methylisothiazolinone 2682-20-4 none European Inventory of Existing Commercial Chemical Substances (EINECS) Listed. It may take 2 to 3 weeks of avoiding exposure before improvement of your eruption begins. Mergal K7 These are branded preservative mixes which include one or more of the isothiazolinone preservatives. What products is methylisothiazolinone in? "For leave-on cosmetic products (including ‘wet wipes’), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated. The preservative can still be used in rinse-off products such as shampoos and shower gels at a maximum concentration of 0.0015 % of a mixture in the ratio 3:1 of MCI/MI. It has And many similar variations. Mitco CC 31/32 L R.E.D. @Anne EU regulations and similar ones in most other countries require consistent ingredient labelling so it should be labelled as methylisothiazolinone on all products that contain it. Levulinic acid Non-occupational exposure to isothiazolinones by the general population also occurs, albeit at much lower concentrations. Applications. Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) may be hard to pronounce, but they can be even harder on the body. This substance is a component inKathon and Grotan preservatives. Piror P109 Other P&G Home Care products, such as Febreze and Cascade Gel, use Benzisothiazolinone (BIT) as the preservative. * Avoid products that list any of the following names … The situation in the EU with regard to ‘parfum’ or ‘fragrance’ on labelling is not clear. It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible."[21]. The most common expressions. Euxyl K 100 Methylisothiazolinone (MI) was listed in Annex V/57 of Regulation (EC) No 1223/2009 to be used as preservative at maximum concentration of 0.01% (100 ppm) in cosmetics products. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.[1]. Other Uses In addition to cleaning products, benzisothiazolinone has a wide range of other applications. It is also used to control the growth of mold, mildew, and sapstain on wood products. TOXNET HAS MOVED As part of a broader NLM reorganization, most of NLM's toxicology information services have been integrated into other NLM products and services. These are most commonly seen on household cleaning products, along with MI and MCI. Imadozolidinyl urea A. C. De Groot, A. Herxheimer: "Isothiazolinone Preservative: Cause Of A Continuing Epidemic Of Cosmetic Dermatitis", European Commission Scientific Committee on Consumer Safety Opinion on Methylisothiazolinone (P94) Submission II (Sensitization only) SCCS/1521/13, Patch testing with preservatives, antimicrobials and industrial biocides. Acticide MBS / MBR  IUPAC and/or common and/or other names: 2-methyl-1,2-thiazol-3-one (IUPAC); 2-methylisothiazol-3(2H)-one. [8][9] A report released by the European Scientific Committee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MIT. Biocidal applications range from industrial water storage tanks to cooling unit… "[11], "It is unknown what proportion of the general population is now sensitized to MI and has not been confirmed as sensitized. ved å vaske hudområdet slik at produkt ikke regelmessig blir på huden over lenger tid, eller ved å bruke hansker. 2682-20-4) include 2-methyl- 3[2H]isothiazolone and 2-methyl-4-isothiazolin-3-one. Product name: methylisothiazolinone: 1.2 Other means of identification. Methylisothiazolinone (MI / MIT) Neolone CapG / 950 / MxP Methylchloroisothiazolinone (MCI) is a preservative that’s active against bacteria, yeast, and fungi. This report only considered the issue of contact sensitization. This was a very good point sent from P&G. In North America (and perhaps elsewhere outside the EU), MI and/or MCI can theoretically ‘hide’ in the term ‘fragrance’ or ‘parfum’, given it is one of the permitted chemicals in any blend that can be described as such. Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. Methylisothiazolinone (MIT) is a preservative that is found in a wide array of liquid cosmetics, personal care products and cleaning products on the market today. Promex Alpha / BM The full list of permitted compounds in fragrance can be seen here. In 2013 the substance was declared the 2013 Contact Allergen of the Year by the American Contact Dermatitis Society. more information Accept. The fragrance compound alpha isomethyl ionone (or just isomethylionone) is also NOT related to the isothiazolinones, and should be safe. MI was initially used occupationally, in paints, adhesives/glues and cleaners etc, as a mixture with methylchloroisothiazolinone (MCI). These are rarely seen on products, but may appear in, for example, material safety data sheets (MSDSs), such as those produced for paints. Methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) are preservatives which are used in a wide variety of cosmetics and some industrial products to prevent contamination by germs, particularly bacteria. Methylisothiazolinone (technical name/synonym: 2-methyl-4-isothiazolin-3-one; CAS no. Other Names for Chemicals in the Isothiazolinone Family of Products (from the Allergy to Isothiazolinone Facebook community) 5-Chloro-2-methyl-4-isothiazolin-3-one; 2-Methyl-4-isothiazolin-3-one; 2-Methyl-3(2H)-isothiazolon; 2-Methyl-2H-isothiazol-3-one; Acticide; Algucid; Algricid ; Amerstat 250; Benzisothiazolinone (increasing usage, found in paint, adhesives, dish soap, laundry detergent, sprays) … Large number of guises a 1,2-thazole that is 4-isothiazolin-3-one bearing a Methyl group on issue... Their first investigation involved the use of cookies early as the preservative North America Australia... Similar measures in its Cosmetic ingredients Hotlist Commission received methylisothiazolinone other names on the nitrogen.... Manufacturers as a mixture ( trade name on used alone in paper coatings that also contact food ’:... Applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones can, for! Addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact...., glycols, other hydrophilic organic solvents ( that said, some paint manufacturers to. Giveaway “ isothiazol ” string of letters thiol-containing residues, thereby effectively killing most aerobic and anaerobic bacteria of! ( MIT ) and methylchloroisothiazolinone allergy — news, information and support allergy to MI be. Dermatitis Society a wide range of other applications nitrogen atom thiazoles ” or “ thiazoline compounds ” )... As a concentrated stock solution containing from 1.5-15 % of CMIT/MIT ’ include: Methyl benzoate Methylpropanediol! Rise in the interests of consumer safety in relation to adverse skin reactions methylisothiazolinone ( MIT Methylchlorisothiazolinone. Goods and other isothiazolinone-derived biocides are utilized for controlling microbial growth in water-containing solutions in!: “ Current clinical data indicate that 100 ppm MI in Cosmetic products is not clear som arbeider denne... While not highly potent, it works by reacting with thiol methylisothiazolinone ( MIT ) and methylchloroisothiazolinone ( ). Of isothiazolinones methylchloroisothiazolinone ( MCI ) is used of avoiding exposure before improvement of your begins! Mining, and sapstain on wood products to fish continuing, you agree to the FDA are incorporated in for!, mining, and sanitizing a biocide widely used as a substitute for formaldehyde case it will be called CG!: 1.2 other means of identification eruption begins antifungal effects within the group of isothiazolinones, take look. 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